期刊
NEURON
卷 71, 期 3, 页码 460-473出版社
CELL PRESS
DOI: 10.1016/j.neuron.2011.06.009
关键词
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资金
- Nakajima Foundation [R01 NS35165]
- NRSA [F31NS056558-01A1]
- Veterans Administration
- Foundation Fighting Blindness
- Foundation pour la Rechereche Medicale
- [R01 NS065048]
- [R01 NS047333]
In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal lamination. However, the mechanisms by which retinal neurites are segregated within the inner or outer plexiform layers are not known. We find that the transmembrane semaphorins Sema5A and Sema5B constrain neurites from multiple retinal neuron subtypes within the inner plexiform layer (IPL). In Serna5A(-/-); Serna5B(-/-) mice, retinal ganglion cells (RGCs) and annacrine and bipolar cells exhibit severe defects leading to neurite mistargeting into the outer portions of the retina. These targeting abnormalities are more prominent in the outer (OFF) layers of the IPL and result in functional defects in select RGC response properties. Sema5A and Sema5B inhibit retinal neurite outgrowth through PlexinA1 and PlexinA3 receptors both in vitro and in vivo. These findings define a set of ligands and receptors required for the establishment of inner retinal lamination and function.
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