期刊
NEURON
卷 69, 期 4, 页码 695-712出版社
CELL PRESS
DOI: 10.1016/j.neuron.2011.02.009
关键词
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资金
- Somaxon
- National Institutes of Health
- Veteran's Administration
- Mohegan Sun Casino
- National Center for Responsible Gaming
- National Institute on Drug Abuse [P50-DA09241, P50-DA016556, P20-DA027844, R37-DA015969, K02-DA021304, R01-DA020908, RC1-DA028279, R01-DA018647, R21 DA029445, R01-DA019039]
- National Institute on Alcoholism and Alcohol Abuse [RL1-AA017539]
- VISN 1 Mental Illness Educational, Research, and Clinical Center (MIRECC)
- Center of Excellence in Gambling Research from the National Center for Responsible Gaming
Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimilate and incorporate relevant information from earlier approaches. In this review, we first briefly review theoretical and biological models of addiction and then describe existing behavioral and pharmacologic therapies for the addictions within this framework. We then propose new directions for treatment development and targets that are informed by recent evidence regarding the heterogeneity of addictions and the neurobiological contributions to these disorders.
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