期刊
NEURON
卷 70, 期 2, 页码 363-374出版社
CELL PRESS
DOI: 10.1016/j.neuron.2011.03.009
关键词
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资金
- Stoicescu Foundation
- Swiss Science Foundation
- Centre d'Imagerie BioMedicale (CIBM) of the University of Lausanne (UNIL)
- Swiss Federal Institute of Technology Lausanne (EPFL)
- University of Geneva (UniGe)
- Centre Hospitalier Universitaire Vaudois (CHUV)
- Hopitaux Universitaires de Geneve (HUG)
- Leenaards Foundation
- Jeantet Foundation
- Swiss National Science Foundation (SNSF) [323530-123718]
- Swiss National Foundation [SINERGIA CRSII1-125135/1]
- Swiss National Science Foundation (SNF) [323530-123718] Funding Source: Swiss National Science Foundation (SNF)
Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental aspect of self-consciousness by altering where healthy subjects experienced themselves to be (self-location). Functional magnetic resonance imaging revealed that temporo-parietal junction (TPJ) activity reflected experimental changes in self-location that also depended on the first-person perspective due to visuo-tactile and visuo-vestibular conflicts. Moreover, in a large lesion analysis study of neurological patients with a well-defined state of abnormal self-location, brain damage was also localized at TPJ, providing causal evidence that TPJ encodes self-location. Our findings reveal that multisensory integration at the TPJ reflects one of the most fundamental subjective feelings of humans: the feeling of being an entity localized at a position in space and perceiving the world from this position and perspective.
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