期刊
NEURON
卷 70, 期 1, 页码 66-81出版社
CELL PRESS
DOI: 10.1016/j.neuron.2011.03.008
关键词
-
资金
- National Institutes of Health [NINDS NS060698]
- University of Hamburg Medical School, DFG [KN556/1-1, KN556/1-2, KN556/1-3, FG885-KN556/4-1, FG885-KN556/4-2]
- Chica and Heinz Schaller Foundation
- Hamburg State Excellence Initiative: Neurodapt
- [DFG-FG885]
Intracellular transport regulates protein turnover including endocytosis. Because of the spatial segregation of F-actin and microtubules, internalized cargo vesicles need to employ myosin and dynein motors to traverse both cytoskeletal compartments. Factors specifying cargo delivery across both tracks remain unknown. We identified muskelin to interconnect retrograde F-actin- and microtubule-dependent GABA(A) receptor (GABA(A)R) trafficking. GABA(A)Rs regulate synaptic transmission, plasticity, and network oscillations. GABA(A)R alpha 1 and muskelin interact directly, undergo neuronal cotransport, and associate with myosin VI or dynein motor complexes in subsequent steps of GABA(A)R endocytosis. Inhibition of either transport route selectively interferes with receptor internalization or degradation. Newly generated muskelin KO mice display depletion of both transport steps and a high-frequency ripple oscillation phenotype. A diluted coat color of muskelin KOs further suggests muskelin transport functions beyond neurons. Our data suggest the concept that specific trafficking factors help cargoes to traverse both F-actin and microtubule compartments, thereby regulating their fate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据