期刊
NEURON
卷 72, 期 2, 页码 202-230出版社
CELL PRESS
DOI: 10.1016/j.neuron.2011.09.021
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [RC4 GM096355, R01 GM067858, T32 GM007526, RC4 GM096355-01, R01 GM067858-09, T32 GM007526-34] Funding Source: Medline
Research in the fruit fly Drosophila melanogaster has led to insights in neural development, axon guidance, ion channel function, synaptic transmission, learning and memory, diurnal rhythmicity, and neural disease that have had broad implications for neuroscience. Drosophila is currently the eukaryotic model organism that permits the most sophisticated in vivo manipulations to address the function of neurons and neuronally expressed genes. Here, we summarize many of the techniques that help assess the role of specific neurons by labeling, removing, or altering their activity. We also survey genetic manipulations to identify and characterize neural genes by mutation, overexpression, and protein labeling. Here, we attempt to acquaint the reader with available options and contexts to apply these methods.
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