期刊
NEURON
卷 69, 期 4, 页码 749-762出版社
CELL PRESS
DOI: 10.1016/j.neuron.2011.01.025
关键词
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资金
- Swiss National Science Foundation [PBSKP3-123456/1]
- National Institute of Health [NS39313]
- Swiss National Science Foundation (SNF) [PBSKP3-123456] Funding Source: Swiss National Science Foundation (SNF)
Homeostatic signaling systems stabilize neural function through the modulation of neurotransmitter receptor abundance, ion channel density, and presynaptic neurotransmitter release. Molecular mechanisms that drive these changes are being unveiled. In theory, molecular mechanisms may also exist to oppose the induction or expression of homeostatic plasticity, but these mechanisms have yet to be explored. In an ongoing electrophysiology-based genetic screen, we have tested 162 new mutations for genes involved in homeostatic signaling at the Drosophila NMJ. This screen identified a mutation in the rab3-GAP gene. We show that Rab3-GAP is necessary for the induction and expression of synaptic homeostasis. We then provide evidence that Rab3-GAP relieves an opposing influence on homeostasis that is catalyzed by Rab3 and which is independent of any change in NMJ anatomy. These data define roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity.
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