期刊
NEURON
卷 65, 期 4, 页码 550-562出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.02.005
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIA NIH HHS [R01 AG034556-03, R01 AG034556-02, R01 AG021910, AG-021910, R01 AG034556-01, R01 AG021910-05] Funding Source: Medline
One of the most consistent observations in human functional imaging is that a network of brain regions referred to as the default network increases its activity during passive states. Here we explored the anatomy and function of the default network across three studies to resolve divergent hypotheses about its contributions to spontaneous cognition and active forms of decision making. Analysis of intrinsic activity revealed the network comprises multiple, dissociated components. A midline core (posterior cingulate and anterior medial prefrontal cortex) is active when people make self-relevant, affective decisions. In contrast, a medial temporal lobe subsystem becomes engaged when decisions involve constructing a mental scene based on memory. During certain experimentally directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged, presumably to facilitate construction of mental models of personally significant events.
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