期刊
NEURON
卷 68, 期 2, 页码 201-206出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.10.014
关键词
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资金
- Wellcome/MRC Parkinson Disease Consortium
- University of Sheffield
- MRC Protein Phosphorylation Unit at the University of Dundee
- MFIC
- Medical Research Council [MC_G1000735, G0701075] Funding Source: researchfish
- Parkinson's UK [G-0907] Funding Source: researchfish
- MRC [MC_G1000735, G0701075] Funding Source: UKRI
In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease.
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