期刊
NEURON
卷 68, 期 3, 页码 387-400出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.09.015
关键词
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资金
- Helen Hay Whitney postdoctoral fellowship
- National Institutes of Health (NIH)
- Burroughs Welcome Fund
- Michael Flynn Stanford Graduate Fellowship
- NIH-NINDS-CRCNS-R01
- National Science Foundation (NSF)
- NIH NINDS [R01-NS054283]
- DARPA [N66001-10-C-2010]
- Stanford Center for Integrated Systems
- NSF Center for Neuromorphic Systems Engineering at Caltech
- Office of Naval Research
- Whitaker Foundation
- [1DP1OD006409]
- [NIH NINDS R01-NS054283]
- [DARPA REPAIR (N66001-10-C-2010)]
- EPSRC [EP/H019472/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H019472/1] Funding Source: researchfish
The motor cortices are active during both movement and movement preparation. A common assumption is that preparatory activity constitutes a subthreshold form of movement activity: a neuron active during rightward movements becomes modestly active during preparation of a rightward movement. We asked whether this pattern of activity is, in fact, observed. We found that it was not: at the level of a single neuron, preparatory tuning was weakly correlated with movement-period tuning. Yet, somewhat paradoxically, preparatory tuning could be captured by a preferred direction in an abstract space that described the population-level pattern of movement activity. In fact, this relationship accounted for preparatory responses better than did traditional tuning models. These results are expected if preparatory activity provides the initial state of a dynamical system whose evolution produces movement activity. Our results thus suggest that preparatory activity may not represent specific factors, and may instead play a more mechanistic role.
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