期刊
NEURON
卷 66, 期 3, 页码 337-351出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.04.028
关键词
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资金
- Medical Research Council
- Royal Society International Joint Projects
- European Union [HEALTH-F2-2009-241498]
- MRC [MC_U122669937] Funding Source: UKRI
- Medical Research Council [MC_U122669937] Funding Source: researchfish
Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.
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