期刊
NEURON
卷 66, 期 2, 页码 235-247出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.03.030
关键词
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资金
- CNRS
- IBRO
- Agence Nationale pour la Recherche [BLAN08-2_313083]
- Fondation pour la Recherche Medicale
- EU [LSHM-CT-2007-037765]
- UK Medical Research Council
- MRC [MC_U117592730, MC_U117532185] Funding Source: UKRI
- Medical Research Council [U117512659, MC_U117532185, MC_U117592730] Funding Source: researchfish
Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents (preminis) that arise by the autocrine activation of axonal receptors following random vesicular release. Preminis are prominent in gabaergic synapses made by cerebellar interneurons during the development of the molecular layer. Unlike ordinary miniature postsynaptic currents in the same cells, premini frequencies are strongly enhanced by subthreshold depolarization, suggesting that the membrane depolarization they produce belongs to a feedback loop regulating neurotransmitter release. Thus, preminis could guide the formation of the interneuron network by enhancing neurotransmitter release at recently formed synaptic contacts.
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