期刊
NEURON
卷 65, 期 6, 页码 912-926出版社
CELL PRESS
DOI: 10.1016/j.neuron.2010.02.011
关键词
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资金
- China Ministry of Science and Technology [863, 973]
- China NSFC Young Investigator Grant
- Human Frontier Science Program
- NIDCD, NIH
In mammals, olfactory sensory neurons (OSNs) expressing a specific odorant receptor (OR) gene project with precise stereotypy onto mitral/tufted (M/T) cells in the main olfactory bulb (MOB). It remains challenging to understand how incoming olfactory signals are transformed into outputs of M/T cells. By recording from OSNs expressing mouse 17 receptor and their postsynaptic neurons in the bulb, we found that 17 OSNs and their corresponding M/T cells exhibit similarly selective tuning profiles at low concentrations. Increasing the concentration significantly reduces response selectivity for both OSNs and M/T cells, although the tuning curve of M/T cells remains comparatively narrow. By contrast, interneurons in the MOB are broadly tuned, and blocking GABAergic neurotransmission reduces selectivity of M/T cells at high odorant concentrations. Our results indicate that olfactory information carried by an OR is channeled to its corresponding M/T cells and support the role of lateral inhibition via interneurons in sharpening the tuning of M/T cells.
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