期刊
NEURON
卷 64, 期 6, 页码 783-790出版社
CELL PRESS
DOI: 10.1016/j.neuron.2009.12.016
关键词
-
资金
- Swiss National Foundation
- Stammbach Foundation
- European Union
- Alzheimer Forschung Initiative e.V.
Recent reports indicate that a growing number of intracellular proteins are not only prone to pathological aggregation but can also be released and infect neighboring cells. Therefore, many complex diseases may obey a simple model of propagation where the penetration of seeds into hosts determines spatial spread and disease progression. We term these proteins prionoids, as they appear to infect their neighbors just like prions-but how can bulky protein aggregates be released from cells and how do they access other cells? The widespread existence of such prionoids raises unexpected issues that question our understanding of basic cell biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据