期刊
NEURON
卷 64, 期 5, 页码 645-662出版社
CELL PRESS
DOI: 10.1016/j.neuron.2009.10.017
关键词
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资金
- BBSRC UK
- Project A.L.S.
- Medical Research Scotland
- NIH [R01 DE/HD12324, DE16329, RO1 NS33245]
- Harold and Leila Mathers Foundation
- Wellcome Trust
- BBSRC [BB/E019803/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E019803/1] Funding Source: researchfish
Mammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive prominent C bouton cholinergic inputs from spinal interneurons, but the source and function of these synaptic inputs have remained obscure. We show here that the transcription factor Pitx2 marks a small cluster of spinal cholinergic interneurons, V0(C) neurons, that represents the sole source of C bouton inputs to motor neurons. The activity of these cholinergic interneurons is tightly phase locked with motor neuron bursting during fictive locomotor activity, suggesting a role in the modulation of motor neuron firing frequency. Genetic inactivation of the output of these neurons impairs a locomotor task-dependent increase in motor neuron firing and muscle activation. Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior.
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