期刊
NEURON
卷 61, 期 5, 页码 692-699出版社
CELL PRESS
DOI: 10.1016/j.neuron.2009.02.012
关键词
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资金
- Howard Hughes Medical Institute
- NIH [R01 HG004321, P50 GM071508]
- James S. McDonnell Foundation
- Damon Runyon Cancer Research Foundation
- Jane Coffin Childs Foundation
Most heritable behavioral traits have a complex genetic basis, but few multigenic traits are understood at a molecular level. Here we show that the C. elegans strains N2 and CB4856 have opposite behavioral responses to simultaneous changes in environmental O-2 and CO2. We identify two quantitative trait loci (QTL) that affect this trait and map each QTL to a single-gene polymorphism. One gene, npr-1, encodes a previously described neuropeptide receptor whose high activity in N2 promotes CO2 avoidance. The second gene, glb-5, encodes a neuronal globin domain protein whose high activity in CB4856 modifies behavioral responses to O-2 and combined O-2/CO2 stimuli. glb-5 acts in O-2-sensing neurons to increase O-2-evoked calcium signals, implicating globins in sensory signaling. An analysis of wild C. elegans strains indicates that the N2 alleles of npr-1 and glb-5 arose recently in the same strain background, possibly as an adaptation to laboratory conditions.
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