期刊
NEURON
卷 62, 期 5, 页码 670-682出版社
CELL PRESS
DOI: 10.1016/j.neuron.2009.04.023
关键词
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资金
- Institut National de la Science et de la Recherche Medicale
- Ministere de la Recherche
- Fondation pour la Recherche Medicale
- Agence National de la Recherche [ANR05-Neuro 043-01]
- Toyobo Biotechnology Foundation
- Japan Society for the Promotion of Science
- Special Postdoctoral Researchers Program in RIKEN
- KAKENHI [20700300]
- Grants-in-Aid for Scientific Research [20700300] Funding Source: KAKEN
An activity-dependent change in synaptic efficacy is a central tenet in learning, memory, and pathological states of neuronal excitability. The lateral diffusion dynamics of neurotransmitter receptors are one of the important parameters regulating synaptic efficacy. We report here that neuronal activity modifies diffusion properties of type-A GABA receptors (GABA(A)R) in cultured hippocampal neurons: enhanced excitatory synaptic activity decreases the cluster size of GABA(A)Rs and reduces GABAergic mIPSC. Single-particle tracking of the GABA(A)R gamma 2 subunit labeled with quantum dots reveals that the diffusion coefficient and the synaptic confinement domain size of GABA(A)R increases in parallel with neuronal activity, depending on Ca2+ influx and calcineurin activity. These results indicate that GABA(A)R diffusion dynamics are directly linked to rapid and plastic modifications of inhibitory synaptic transmission in response to changes in intracellular Ca2+, concentration. This transient activity-dependent reduction of inhibition would favor the onset of LTP during conditioning.
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