期刊
NEURON
卷 59, 期 5, 页码 733-745出版社
CELL PRESS
DOI: 10.1016/j.neuron.2008.07.024
关键词
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资金
- Spanish Ministry of Education and Science [BFU2005-04773/BMC]
- CONSOLIDER [CSD2007-00023]
- Fundacio la Caixa
- European Commission [005139 (INTERDEVO)]
- EURYI
- NINDS
- NIMH
- UK Medical Research Council
- European Research Council
- Foundation for Science and Technology [POCI 2010/FSE]
- Medical Research Council [G0501173] Funding Source: researchfish
- MRC [G0501173] Funding Source: UKRI
The homeodomain transcription factor Nkx2-1 plays key roles in the developing telencephalon, where it regulates the identity of progenitor cells in the medial ganglionic eminence (MGE) and mediates the specification of several classes of GABAergic and cholinergic neurons. Here, we have investigated the post-mitotic function of Nkx2-1 in the migration of interneurons originating in the MGE. Experimental manipulations and mouse genetics show that down-regulation of Nkx2-1 expression in postmitotic cells is necessary for the migration of interneurons to the cortex, whereas maintenance of Nkx2-1 expression is required for interneuron migration to the striatum. Nkx2-1 exerts this role in the migration of MGE-derived interneurons by directly regulating the expression of a guidance receptor, Neuropilin-2, which enables interneurons to invade the developing striatum. Our results demonstrate a role for the cell-fate determinant Nkx2-1 in regulating neuronal migration by direct transcriptional regulation of guidance receptors in postmitotic cells.
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