期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 142, 期 -, 页码 110-117出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2015.01.081
关键词
Deferiprone; Iron; Sequential injection
类别
资金
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Mahasarakham University
- IDEAS research institute
We present for the first time the use of deferiprone as a non-toxic complexing agent for the determination of iron by sequential injection analysis in pharmaceuticals and food samples. The method was based on the reaction of Fe( III) and deferiprone in phosphate buffer at pH 7.5 to give a Fe(III)-deferiprone complex, which showed a maximum absorption at 460 nm. Under the optimum conditions, the linearity range for iron determination was found over the range of 0.05-3.0 mu g mL(-1) with a correlation coefficient (r(2)) of 0.9993. The limit of detection and limit of quantitation were 0.03214 mL(-1) and 0.055 mu g mL(-1), respectively. The relative standard deviation (%RSD) of the method was less than 5.0% (n = 11), and the percentage recovery was found in the range of 96.0-104.0%. The proposed method was satisfactorily applied for the determination of Fe(III) in pharmaceuticals, water and food samples with a sampling rate of 60 h(-1). (C) 2015 Elsevier B.V. All rights reserved.
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