期刊
NEUROMUSCULAR DISORDERS
卷 22, 期 1, 页码 16-25出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nmd.2011.06.750
关键词
Duchenne muscular dystrophy; Muscle strength; Magnetic resonance imaging
资金
- Muscular Dystrophy Association [MDA4170]
- Parent Project Muscular Dystrophy [8509]
- National Institutes of Health
- specifically a Senator Paul D. Wellstone Muscular Dystrophy Research Center [U54AR 052646, R01AR056973]
- Grants-in-Aid for Scientific Research [23650432] Funding Source: KAKEN
The purpose of this study was to assess the contractile and non-contractile content in thigh muscles of patients with Duchenne muscular dystrophy (DMD) and determine the relationship with functional abilities. Magnetic resonance images of the thigh were acquired in 28 boys with DMD and 10 unaffected boys. Muscle strength, timed functional tests, and the Brookes Lower Extremity scale were also assessed. Non-contractile content in the DMD group was significantly greater than in the control group for six muscles, including rectus femoris, biceps femoris-long head and adductor magnus. Non-contractile content in the total thigh musculature assessed by MRI correlated with the Brookes scale (r(s) = 0.75) and supine-up test (r(s) = 0.68), as well as other functional measures. An age-related specific torque increase was observed in the control group (r(s) = 0.96), but not the DMD (r(s) = 0.06). These findings demonstrate that MRI measures of contractile and non-contractile content can provide important information about disease progression in DMD. (C) 2011 Elsevier B.V. All rights reserved.
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