期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 150, 期 -, 页码 207-211出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2015.05.059
关键词
Indomethacin; Terahertz time-domain spectroscopy; Hydrogen bonding; Intermolecular vibration; Boson peak
类别
资金
- JSPS [24740194]
- Sasakawa Scientific Research Grant from The Japan Science Society
- Casio Science Promotion Foundation
- Grants-in-Aid for Scientific Research [24740194] Funding Source: KAKEN
In order to clarify the intermolecular vibrations, the low-frequency modes of the glassy and crystalline states of model pharmaceutical indomethacin have been studied using broadband terahertz time-domain spectroscopy and low-frequency Raman scattering. In the crystalline gamma-form, the center of symmetry was suggested by the observation of the exclusion principle of the infrared (IR) and Raman selection rules in the frequency range between 0.2 and 6.5 THz. In addition, a boson peak of the glassy state was observed in both IR and Raman spectra and their frequency showed apparent discrepancy. The intermediate correlation length of the glassy structure was estimated to be about 2.5 nm. The existence of hydrogen bonded cyclic dimers in a glassy state was suggested by the observation of the infrared active intermolecular vibrational mode of the hydrogen bonded cyclic dimers as a broad peak at 3.0 THz in the IR spectrum. (c) 2015 Elsevier B.V. All rights reserved.
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