期刊
NEUROMUSCULAR DISORDERS
卷 19, 期 7, 页码 462-467出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nmd.2009.06.369
关键词
Non-dystrophic myotonias; Chloride channelopathies; Sodium channelopathies; Muscle ultrasound; Structural muscle changes
资金
- Prinses Beatrix Fonds, The Hague, The Netherlands [Mar04-0118]
Patients with non-dystrophic myotonias, including chloride (myotonia congenita) and sodium channelopathies (paramyotonia congenita/potassium aggravated myotonias), may show muscular hypertrophy in combination with some histopathological abnormalities. However, the extent of muscle changes has never been assessed objectively in a large group genetically confirmed patients. This study quantitatively determines echo intensities, thicknesses, ranges-of-motion and force of four skeletal muscles in 63 genetically confirmed patients. The main findings revealed elevated echo intensities in all Muscles except the rectus femoris (+1.3-2.2 SID, p < 0.0001), and hypertrophy in the arms (+0.5-0.9 SD, p < 0.01). Muscle echo intensities were inversely correlated to the corresponding ranges-of-motion (biceps brachii: r=-0.43; p < 0.001, forearm flexors: r = -0.47: p < 0.001, rectus femoris: r = -0.40; p = 0.001, and tibial anterior: r = -0.27; p = 0.04) and correlated positively to age (r = 0.22; p = 0.05). The echo intensity of the forearm flexors was inversely correlated to their muscles' force (r = -0.30; p = 0.02). Together, these data suggest that non-dystrophic myotonias may lead to structural muscle changes. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据