期刊
NEUROMOLECULAR MEDICINE
卷 16, 期 2, 页码 448-456出版社
HUMANA PRESS INC
DOI: 10.1007/s12017-014-8291-0
关键词
SIRT2; APOE epsilon 4; Single-nucleotide polymorphism; Alzheimer's disease; Susceptibility; Meta-analysis
资金
- National High Technology Research and Development Program of China (863) [2012AA02A508]
- International Cooperation Program [2012DFA 30470]
- National Natural Science Foundation of China [91229121, 81272792, 81172389, 81372709, 81302185, 81101901, 81302184]
- Jiangsu Province's Natural Science Foundation [BK2011847, 20131019]
- Jiangsu Province's Key Provincial Talents Program [RC2011051]
- Jiangsu Province's Key Discipline of Medicine [XK201117]
- Jiangsu Provincial Special Program of Medical Science [BL2012028]
- Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Previous studies have reported an association between human sirtuins' single-nucleotide polymorphisms (SNPs) and Alzheimer's disease (AD) susceptibility in the apolipoprotein E (APOE) epsilon 4-negative population, although the findings are inconsistent. To obtain a more precise estimation of this relationship, we conducted a meta-analysis to assess the association between the rs10410544 C/T polymorphism of SIRT2 and the risk of AD with APOE epsilon 4 status. We searched all relevant PubMed publications and included three studies in our meta-analysis involving a total of 1,794 patients and 2,054 control subjects. Odds ratios (ORs) with 95 % confidence intervals (CIs) were employed to evaluate the association of the SIRT2 SNP with AD susceptibility, and we analyzed the extracted data stratified by the APOE epsilon 4-carrying status. Overall, the results show that the SIRT2 SNP is associated with human AD risk in the comparison models (T vs. C: OR 1.140, 95 % CI 1.034-1.258; TC vs. CC: OR 1.178, 95 % CI 1.019-1.361; TT + TC vs. CC: OR 1.197, 95 % CI 1.043-1.373). In the stratified analyses, the European population had a significantly increased risk of AD (T vs. C: OR 1.110, 95 % CI 1.002-1.229), and we also observed a significant association in the APOE epsilon 4-negative population (T vs. C: OR 1.165, 95 % CI 1.025-1.324; TT + TC vs. CC: OR 1.222, 95 % CI 1.022-1.461). This meta-analysis indicates that the presence of the SIRT2 SNP with APOE epsilon 4-negative status contributes to the development of AD in humans Epidemiological studies of larger sample sizes are warranted to confirm this hypothesis.
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