期刊
NEUROMODULATION
卷 16, 期 5, 页码 407-413出版社
WILEY
DOI: 10.1111/ner.12052
关键词
adverse event; complication; deep brain stimulation; hemorrhage; venous infarction
资金
- National Parkinson Foundation Center of Excellence
- UF INFORM data base
- McKnight Brain Institute
- University of Florida and Shands
- NIH/NINDS [K23 NS044997]
- St. Luke's Life Science Institute of Japan
- Japan Society for Promotion of Science in Japan
ObjectDespite numerous reports on the morbidity and mortality of deep brain stimulation (DBS), cerebral venous infarction has rarely been reported. We present four cases of venous infarct secondary to DBS surgery. MethodsThe diagnosis of venous infarction was based on 1) delayed onset of new neurologic deficits on postoperative day 1 or 2; 2) significant edema surrounding the superficial aspect of the implanted lead, with or without subcortical hemorrhage on CT scan. ResultsFour cases (0.8% per lead, 1.3% per patient) of symptomatic cerebral venous infarction were identified out of 500 DBS lead implantation procedures between July 2002 and August 2009. All four patients had Parkinson's disease. Their DBS leads were implanted in the subthalamic nucleus (n = 2), and the globus pallidus internus (n = 2). Retrospective review of the targeting confirmed that the planned trajectory passed within 3mm of a cortical vein in two cases for which contrast-enhanced preoperative magnetic resonance (MR) imaging was available. In the other two cases, contrasted targeting images were not obtained preoperatively. ConclusionCerebral venous infarction is a potentially avoidable, but serious complication. To minimize its incidence, we propose the use of high-resolution, contrast-enhanced, T1-weighted MR images to delineate cerebral venous anatomy, along with careful stereotactic planning of the lead trajectory to avoid injury to venous structures.
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