β-Amyloidosis and neurodegeneration in Alzheimer disease Who's on first?

Over the past decade, there has been an explosion of research describing the relationship between brain -amyloidosis as measured by PET imaging using C-11-Pittsburgh compound B-1 or florbetapir.(2) Two articles(3,4) in this issue of Neurology (R) add additional observations. The purpose of this editorial is to describe a conceptual model of Alzheimer disease (AD) pathophysiology that enables the reader to put the current findings into perspective.