期刊
NEUROLOGY
卷 80, 期 14, 页码 1307-1314出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e31828ab2c9
关键词
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资金
- Bristol-Myers Squibb
- S and L Marx Foundation
- National Institutes of Health [NIA-AG03949]
- NIH [P01 AG039409, P01AG027734, 5R01 AG22374, 2U01AG012535-16, R01 AG039330, R01 AG036921, R01 HL094581, P01 AG03949, PO1 AG03949, PO1AG027734, RO1AG025119, RO1AG022374-06A2, RO1AG034119, RO1AG12101, K23AG030857, K23NS05140901A1, K23NS47256]
- NCRR [5UL1RR025750-03]
- NIH-NIA [P01 AG039409, P01 AG027734, R01 AG022374, R01 AG034119, R01 AG012101, AG038651]
- Alzheimer's Association [NIRG-11-206369]
- Merck
- Allergan
- American Headache Society
- Autonomic Technologies
- Boston Scientific
- Cognimed
- Colucid
- Eli Lilly
- Endo
- eNeura Therapeutics
- GlaxoSmithKline
- MAP
- Nautilus Neuroscience
- Novartis
- NuPathe
- Pfizer
Objective: Data from the Einstein Aging Study (EAS) were used to prospectively evaluate the free recall score from the Free and Cued Selective Reminding Test (FCSRT-FR) and Logical Memory I immediate recall (LM-IR) subtest of the Wechsler Memory Scale-Revised for prediction of incident Alzheimer disease (AD) dementia among individuals from a community-based cohort with memory complaints. Methods: Analyses included 854 participants, age >= 70 years, who initially had no dementia, and had memory complaints. Clinic evaluations were completed annually and AD dementia was diagnosed using standard criteria (n = 86 cases; average follow-up 4.1 years). Time-dependent receiver operating characteristic analysis was used to evaluate the prognostic ability of FCSRT-FR and LM-IR for incident AD over various durations of follow-up. Results: For identifying those with memory complaints who will develop incident AD dementia over 2-4 years, the FCSRT-FR had better operating characteristics than LM-IR. APOE epsilon 4 status, age, and education did not affect cut points; however, positive predictive values were higher among APOE epsilon 4-positive individuals. Conclusions: For follow-up intervals of 2-4 years, the FCSRT-FR is more predictive than the LM-IR for identifying individuals with memory complaints who will develop incident AD. APOE epsilon 4 status improves positive predictive value, but does not affect the choice of optimal cuts. Neurology (R) 2013;80:1307-1314
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