期刊
NEUROLOGY
卷 80, 期 9, 页码 829-838出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3182840689
关键词
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资金
- European Community (Fifth Framework Programme) [QLK4CT199900927]
- Compagnia di San Paolo
- Europe Against Cancer Program of the European Commission (SANCO)
- ISCIII, Red de Centros RCESP [C03/09]
- Deutsche Krebshilfe
- Deutsches Krebsforschungszentrum
- German Federal Ministry of Education and Research
- Danish Cancer Society
- Health Research Fund (FIS) of the Spanish Ministry of Health
- Spanish Regional Government of Andalucia
- Spanish Regional Government of Asturias
- Spanish Regional Government of Basque Country
- Spanish Regional Government of Murcia
- Spanish Regional Government of Navarra
- Cancer Research UK
- Medical Research Council, United Kingdom
- Stroke Association, United Kingdom
- British Heart Foundation
- Department of Health, United Kingdom
- Food Standards Agency, United Kingdom
- Wellcome Trust, United Kingdom Greek Ministry of Healt
- Greek Ministry of Education
- Italian Association for Research on Cancer (AIRC)
- Italian National Research Council
- Dutch Ministry of Public Health, Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (the Netherlands)
- Swedish Cancer
- Swedish Scientific Council
- Regional Government of Skane and Vasterbotten, Sweden
- Norwegian Cancer Society
- Research Council of Norway
- French League Against Cancer, INSERM
- Mutuelle Generale l'Education National
- IGR
- Cancer Research UK [14136] Funding Source: researchfish
- Medical Research Council [G1000143, G0801056B, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10084, NF-SI-0512-10114] Funding Source: researchfish
Objectives: The aim of this study was to investigate for the first time the association between body fat and risk of amyotrophic lateral sclerosis (ALS) with an appropriate prospective study design. Methods: The EPIC (European Prospective Investigation into Cancer and Nutrition) study included 518,108 individuals recruited from the general population across 10 Western European countries. At recruitment, information on lifestyle was collected and anthropometric characteristics were measured. Cox hazard models were fitted to investigate the associations between anthropometric measures and ALS mortality. Results: Two hundred twenty-two ALS deaths (79 men and 143 women) occurred during the follow-up period (mean follow-up = 13 years). There was a statistically significant interaction between categories of body mass index and sex regarding ALS risk (p = 0.009): in men, a significant linear decrease of risk per unit of body mass index was observed (hazard ratio = 0.93, 95% confidence interval 0.86-0.99 per kg/m(2)); among women, the risk was more than 3-fold increased for underweight compared with normal-weight women. Among women, a significant risk reduction increasing the waist/hip ratio was also evident: women in the top quartile had less than half the risk of ALS compared with those in the bottom quartile (hazard ratio = 0.48, 95% confidence interval 0.25-0.93) with a borderline significant p value for trend across quartiles (p = 0.056). Conclusion: Increased prediagnostic body fat is associated with a decreased risk of ALS mortality. Neurology (R) 2013; 80: 829-838
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