期刊
NEUROLOGY
卷 80, 期 7, 页码 610-615出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e318281ccec
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资金
- Oxford NIHR Biomedical Research Centre
- Medical Research Council
- Motor Neurone Disease Association UK Lady Edith Wolfson Fellowship
- Motor Neurone Disease Association UK Care Centre Program
- NIH [R01EB000822]
- MRC [MR/K01014X/1, G0701923] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C519938/1] Funding Source: researchfish
- Medical Research Council [MR/K01014X/1, G0701923] Funding Source: researchfish
- Motor Neurone Disease Association [Turner/Jan13/944-795] Funding Source: researchfish
Objective: To demonstrate the sensitivity of a recently developed whole-brain magnetic resonance spectroscopic imaging (MRSI) sequence to cerebral pathology and disability in amyotrophic lateral sclerosis (ALS), and compare with measures derived from diffusion tensor imaging. Methods: Whole-brain MRSI and diffusion tensor imaging were undertaken in 13 patients and 14 age-similar healthy controls. Mean N-acetylaspartate (NAA), fractional anisotropy, and mean diffusivity were extracted from the corticospinal tract, compared between groups, and then in relation to disability in the patient group. Results: Significant reductions in NAA were found along the course of the corticospinal tracts on whole-brain MRSI. There were also significant changes in fractional anisotropy (decreased) and mean diffusivity (increased) in the patient group, but only NAA showed a significant relationship with disability (r = 0.65, p = 0.01). Conclusion: Whole-brain MRSI has potential as a quantifiable neuroimaging marker of disability in ALS. It offers renewed hope for a neuroimaging outcome measure with the potential for harmonization across multiple sites in the context of a therapeutic trial. Neurology (R) 2013;80:610-615
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