Synthesis and spectroscopy studies of the inclusion complex of 3-amino-5-methyl pyrazole with beta-cyclodextrin

Amino pyrazole belongs to anti-inflammatory class, and is characterized by a low solubility in water. (In order to increase its solubility in water, inclusion complex of amino pyrazole with beta-CD was obtained.) The inclusion complex obtained between AMP and beta-cyclodextrin, was characterized by FT-IR, H-1 NMR, H-1-H-1 NOESY, C-13 NMR, DEPT, XHCOR, spectra, through TG analysis, DTA, DSC and Scanning Electron Microscopy (SEM). The stoichiometry of inclusion complex is 1:1 (guest host) and K stability is 1.1 x 10(4) M-1. (C) 2014 Elsevier B.V. All rights reserved.