期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 134, 期 -, 页码 10-16出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2014.06.095
关键词
Mixed micelle cloud point extraction; Magnetic dispersive mu-solid phase extraction; Doxazosin; Alfuzosin; Fluorescence
类别
资金
- National Natural Science Foundation of China [21171110]
- Research Fund for the Doctoral Program of Higher Education of China [20091404110001]
Mixed micelle cloud point extraction (MM-CPE) combined with magnetic dispersive mu-solid phase extraction (MD-mu-SPE) has been developed as a new approach for the extraction of doxazosin (DOX) and alfuzosin CALF) prior to fluorescence analysis. The mixed micelle anionic surfactant sodium dodecyl sulfate and non-ionic polyoxyethylene(7.5)nonylphenylether was used as the extraction solvent in MM-CPE, and diatomite bonding Fe3O4 magnetic nanoparticles were used as the adsorbent in MD-mu-SPE. The method was based on MM-CPE of DOX and ALF in the surfactant-rich phase. Magnetic materials were used to retrieve the surfactant-rich phase, which easily separated from the aqueous phase under magnetic field. At optimum conditions, a linear relationship between DOX and ALF was obtained in the range of 5-300 ng mL(-1), and the limits of detection were 0.21 and 0.16 ng mL(-1), respectively. The proposed method was successfully applied for the determination of the drugs in pharmaceutical preparations, urine samples, and plasma samples. (C) 2014 Elsevier B.V. All rights reserved.
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