期刊
NEUROLOGY
卷 78, 期 5, 页码 342-351出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3182452862
关键词
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资金
- NIH [P50 AG016574, U01 AG006786, K01 MH068351, K01 AG028573]
- Robert Wood Johnson Foundation
- Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program
- Rochester Epidemiology Project [R01 AG034676]
- NIH
- Abbott
- Mayo CTSA
- RWJ Foundation
- Cephalon, Inc.
- Allon Therapeutics, Inc.
- NIH/NIA
- Alzheimer's Association
- Mangurian Foundation
- Baxter International, Inc.
- Elan Corporation
- NATIONAL INSTITUTE OF MENTAL HEALTH [K01MH068351] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG034676, K01AG028573, P50AG016574, U01AG006786] Funding Source: NIH RePORTER
Objective: Although incidence rates for mild cognitive impairment (MCI) have been reported, few studies were specifically designed to measure the incidence of MCI and its subtypes using published criteria. We estimated the incidence of amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in men and women separately. Methods: A population-based prospective cohort of Olmsted County, MN, residents ages 70-89 years on October 1, 2004, underwent baseline and 15-month interval evaluations that included the Clinical Dementia Rating scale, a neurologic evaluation, and neuropsychological testing. A panel of examiners blinded to previous diagnoses reviewed data at each serial evaluation to assess cognitive status according to published criteria. Results: Among 1,450 subjects who were cognitively normal at baseline, 296 developed MCI. The age-and sex-standardized incidence rate of MCI was 63.6 (per 1,000 person-years) overall, and was higher in men (72.4) than women (57.3) and for aMCI (37.7) than naMCI (14.7). The incidence rate of aMCI was higher for men (43.9) than women (33.3), and for subjects with <= 12 years of education (42.6) than higher education (32.5). The risk of naMCI was also higher for men (20.0) than women (10.9) and for subjects with <= 12 years of education (20.3) than higher education (10.2). Conclusions: The incidence rates for MCI are substantial. Differences in incidence rates by clinical subtype and by sex suggest that risk factors for MCI should be investigated separately for aMCI and naMCI, and in men and women. Neurology (R) 2012;78:342-351
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