期刊
NEUROLOGY
卷 78, 期 3, 页码 202-209出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e31823fcd87
关键词
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资金
- Merck Co., Inc.
- Allergan, Inc.
- Helsinki University Central Hospital
- University Hospital of Oulu, Finland
- Boehringer Ingelheim
- Lundbeck Inc.
- Orion Corporation
- Menarini Group
- Bayer Schering Pharma
- Maija and Matti Vaskio Foundation of the Finnish Medical Foundation
- Biomedicum Helsinki Foundation
- Wellcome Trust
- USPHS/NIH (NIGMS, NHGRI, NHLBI)
- Academy of Finland
- EuroHead
- GenomEUtwin
- Folkhalsan Research Foundation
- University of Helsinki
- Sigrid Juselius Foundation
- European Union
- Understodsforeningen Liv och Halsa
Objectives: To describe clinical characteristics and to identify susceptibility loci for epilepsy and migraine in a Finnish family with a complex phenotype. Methods: Participating family members were interviewed and medical files were reviewed. The seizure classification was made according to International League Against Epilepsy criteria. Migraine diagnosis was made using the validated Finnish Migraine Specific Questionnaire for Family Studies and criteria according to the current International Classification of Headache Disorders-II. DNA samples were obtained from 56 family members and nonparametric genome-wide linkage analyses were performed using 382 polymorphic microsatellite markers. The most promising loci were fine-mapped with additional microsatellite markers. Results: Clinical data were obtained from 60 family members of whom 12 (20%) had idiopathic epileptic seizures. Eight of those 12 (67%) also had migraine. Altogether 33 of the 60 family members (55%) had migraine. Significant evidence of linkage was found between a locus on 14q12-q23 and migraine (p = 0.0001). Suggestive evidence of linkage in this region was also found for epilepsy with generalized tonic-clonic seizures (p = 0.0034). In addition, significant evidence of linkage was found at a locus on 12q24.2-q24.3 (p < 0.001) for migraine alone and for the combined phenotype of migraine and epilepsy. Conclusions: Our data suggest the occurrence of common susceptibility loci for epilepsy and migraine on chromosomes 14q12-q23 and 12q24.2-q24.3, implicating a shared genetic etiology for these 2 diseases. Neurology (R) 2012;78:202-209
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