期刊
NEUROLOGY
卷 77, 期 6, 页码 580-588出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e318228c0b1
关键词
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资金
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 571]
- BMBF (Krankheitsbezogenes Kompetenznetz Multiple Sklerose), Excellence Initiative of the Ludwig-Maximilians-University Munich
- FoeFoLe of the Ludwig-Maximilians-University
- Gemeinnutzige Hertie Stiftung
- Research Foundation of the MS Society of Canada to the Canadian Pediatric Demyelinating Disease Study Group
- Bayer Schering Pharma
- Teva Pharmaceutical Industries Ltd.
- Merck Serono
- Novartis
- Biogen Idec
- BMBF
- ENS
- University of Wisconsin
- CMSC
- LACTRIMS
- NMSS
- sanofi-aventis
- Swedish Research Council
- EU
- Soderbergs Foundation
- Bibbi and Nils Jensens Foundation
- Montel Williams Foundation
- Swedish Brain foundation
- Tourette Syndrome Association, USA
- Brain Foundation Australia
- Trish Multiple Sclerosis Foundation Australia
- American Tourette Syndrome Association
- Brain Foundation
- Multiple Sclerosis Society of Canada
- Multiple Sclerosis Scientific Research Foundation
- Canadian Institutes of Health Research
- Genentech, Inc.
- Novartis Foundation
- German Research Foundation
- Swiss MS Society
Objective: To study the longitudinal dynamics of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in childhood demyelinating diseases. Methods: We addressed the kinetics of anti-MOG immunoglobulins in a prospective study comprising 77 pediatric patients. This was supplemented by a cross-sectional study analyzing 126 pediatric patients with acute demyelination and 62 adult patients with multiple sclerosis (MS). MOG-transfected cells were used for detection of antibodies by flow cytometry. Results: Twenty-five children who were anti-MOG immunoglobulin (Ig) positive at disease onset were followed for up to 5 years. Anti-MOG antibodies rapidly and continuously declined in all 16 monophasic patients with acute disseminated encephalomyelitis and in one patient with clinically isolated syndrome. In contrast, in 6 of 8 patients (75%) eventually diagnosed with childhood MS, the antibodies to MOG persisted with fluctuations showing a second increase during an observation period of up to 5 years. Antibodies to MOG were mainly IgG 1 and their binding was largely blocked by pathogenic anti-MOG antibodies derived from a spontaneous animal model of autoimmune encephalitis. The cross-sectional part of our study elaborated that anti-MOG Ig was present in about 25% of children with acute demyelination, but in none of the pediatric or adult controls. Sera from 4/62 (6%) adult patients with MS had anti-MOG IgG at low levels. Conclusions: The persistence or disappearance of antibodies to MOG may have prognostic relevance for acute childhood demyelination. Neurology (R) 2011;77:580-588
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