期刊
NEUROLOGY
卷 76, 期 4, 页码 383-389出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3182088297
关键词
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资金
- UCB
- Epilepsy Research Foundation
- GlaxoSmithKline
- Sanofi-Aventis
- Janssen-Cilag
- Novartis
- Pfizer Inc.
- Eisai Inc.
- National Institute for Health Research (NIHR) [RP-PG-0606-1062]
- NEAD study National Institute of Health [2 R01 NS038455]
- National Lottery Charities Board [UK RB219738]
- Epilepsy Research UK
- Medical Research Council UK
- Epilepsy Action UK
Objective: Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97). Methods: Children were recruited prospectively from 2 cohorts in the United Kingdom and assessed using the Griffiths Mental Development Scale (1996), aged <24 months. Information regarding maternal demographics were collected and controlled for. This is an observational study with researchers not involved in the clinical management of the WWE. Results: On overall developmental ability, children exposed to LEV obtained higher developmental scores when compared to children exposed to VPA (p < 0.001). When compared, children exposed to LEV did not differ from control children (p < 0.62) on overall development. Eight percent of children exposed to LEV in utero fell within the below average range (DQ score of <84), compared with 40% of children exposed to VPA. After controlling for maternal epilepsy and demographic factors using linear regression analysis, exposure to LEV in utero was not associated with outcome (p = 0.67). Conversely, when compared with VPA exposure, LEV exposure was associated with higher scores for the overall developmental quotient (p < 0.001). Conclusion: Children exposed to LEV in utero are not at an increased risk of delayed early cognitive development under the age of 24 months. LEV may therefore be a preferable drug choice, where appropriate, for WWE prior to and of childbearing age. Neurology (R) 2011;76:383-389
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