期刊
NEUROLOGY
卷 77, 期 19, 页码 1761-1767出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e318236ef60
关键词
-
资金
- Michael J Fox Foundation for Parkinson's disease
- Nantes University Hospital (Direction de la Recherche Clinique)
- France Parkinson
- Fondation de France
- Aramise
- FFPG (Federation francaise des groupements parkinsoniens)
- Parkinsoniens de Vendee
- Italian Ministry of University
- Research (COFIN projects)
- University of Bologna
- Fondazione Del Monte di Bologna e Ravenna, Bologna, Italy
- Aramise Federation francaise des groupements parkinsoniens
- Fondation de France Parkinsoniens de Vendee
- Ministry of Science Research and Education of Italy
- Ministry of Public Health of Italy
- Fondazione Del Monte di Bologna e Ravenna
Lewy pathology in Parkinson disease (PD) extends well beyond the CNS, also affecting peripheral autonomic neuronal circuits, especially the enteric nervous system (ENS). The ENS is an integrative neuronal network also referred to as the brain in the gut because of its similarities to the CNS. We have recently shown that the ENS can be readily analyzed using routine colonic biopsies. This led us to propose that the ENS could represent a unique window to assess the neuropathology in living patients with PD. In this perspective, we discuss current evidence which indicates that the presence of ENS pathology may by exploited to improve our understanding and management of PD and likely other neurodegenerative disorders. Neurology (R) 2011;77:1761-1767
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据