期刊
NEUROLOGY
卷 77, 期 22, 页码 1972-1976出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e31823a0c90
关键词
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资金
- NIH/NINDS [R01-NS32375]
- Epilepsy Foundation
- National EpiFellows Foundation
- NIH/NINDS
- Eisai Inc.
- British Pediatric Neurological Association
- Epilepsy Research Center (Melbourne)
- UCB
- American Epilepsy Society
- International League Against Epilepsy
- French National Foundation on Alzheimer's Disease and Related Disorders
- NIH
- Genentech, Inc.
- NIH (NIA, NINDS)
- US Veterans Administration Health Services Research and Development Service
- California Office of Statewide Health Planning and Development
- California Department of Public Health
- State of California Department of Health Services
- University of Pennsylvania Udall Center
- American Heart Association
- National Multiple Sclerosis Society
- SCAN Foundation
- Marinus Pharmaceuticals, Inc.
- Sunovion Pharmaceuticals Inc.
- Novartis
- Lundbeck Inc.
- Vertex Pharmaceuticals
- NeuroPace, Inc.
- Medtronics, Inc.
- Sepracor Inc.
- Finding a Cure for Epilepsy and Seizures (FACES)
- Pfizer Inc.
Objective: This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. Methods: Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case status (none, mild, or moderate/severe) were assessed using the Beck Depression Inventory (BDI) preoperatively and 3, 12, 24, 48, and 60 months postoperatively. A mixed-model repeated-measures analysis was performed, adjusting for covariates of seizure location, gender, age, race, education, and seizure control. Results: Of the total 373 subjects, 256 were evaluated at baseline and 5 years after surgery. At baseline, 164 (64.1%) were not depressed, 34 (13.3%) were mildly depressed, and 58 (22.7%) had moderate to severe depression. After 5 years, 198 (77.3%) were not depressed, 20 (7.8%) were mildly depressed, and 38 (14.8%) were moderately to severely depressed. Five years after surgery, the reduction in mean change from baseline in BDI score was greater in subjects with excellent seizure control than in the fair and poor seizure control groups (p = 0.0006 and p = 0.02 respectively). Those with good seizure control had a greater reduction in BDI score than the poor seizure control group (p = 0.02) and borderline significant reduction compared with the fair seizure control group (p = 0.055). Conclusion: Although study participants had initial improvement in depressive symptoms, on average, after resective surgery, only patients with good or excellent seizure control had sustained long-term improvement in mood. Neurology (R) 2011;77:1.972-1976
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