期刊
NEUROLOGY
卷 75, 期 16, 页码 1415-1422出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3181f88359
关键词
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资金
- National Institute on Aging [AG-023629, R01 AG-15928, R01 AG-20098, AG-027058]
- National Heart, Lung, and Blood Institute [U01 HL080295, R01 HL-075366]
- National Institute of Neurological Disorders and Stroke
- University of Pittsburgh Claude D. Pepper Older Americans Independence Center [P30-AG-024827]
- American Heart Association [0815465D]
- NIH [NIA P50 AG05133-24, AG20098-07, NCCAM 5 U01 AT00162-08, U01A1035041, R03MH081723, R03MH081721, R03DA025986, P01AG05133, R01AG20098]
- Fundacio ACEUS Department of Defense
- Fulbright Commission
- [N01-HC-85079]
- [N01-HC-85086]
- [N01-HC-35129]
- [N01 HC-15103]
- [N01 HC-55222]
- [N01-HC-75150]
- [N01-HC-45133]
Objectives: Physical activity (PA) has been hypothesized to spare gray matter volume in late adulthood, but longitudinal data testing an association has been lacking. Here we tested whether PA would be associated with greater gray matter volume after a 9-year follow-up, a threshold could be identified for the amount of walking necessary to spare gray matter volume, and greater gray matter volume associated with PA would be associated with a reduced risk for cognitive impairment 13 years after the PA evaluation. Methods: In 299 adults (mean age 78 years) from the Cardiovascular Health Cognition Study, we examined the association between gray matter volume, PA, and cognitive impairment. Physical activity was quantified as the number of blocks walked over 1 week. High-resolution brain scans were acquired 9 years after the PA assessment on cognitively normal adults. White matter hyper-intensities, ventricular grade, and other health variables at baseline were used as covariates. Clinical adjudication for cognitive impairment occurred 13 years after baseline. Results: Walking amounts ranged from 0 to 300 blocks (mean 56.3; SD 69.7). Greater PA predicted greater volumes of frontal, occipital, entorhinal, and hippocampal regions 9 years later. Walking 72 blocks was necessary to detect increased gray matter volume but walking more than 72 blocks did not spare additional volume. Greater gray matter volume with PA reduced the risk for cognitive impairment 2-fold. Conclusion: Greater amounts of walking are associated with greater gray matter volume, which is in turn associated with a reduced risk of cognitive impairment. Neurology 201.0;75:1415-1422
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