期刊
NEUROLOGY
卷 75, 期 15, 页码 1381-1387出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0b013e3181f736a1
关键词
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资金
- Larry L. Hillblom Foundation
- National Institutes of Health [1R01EB009756, NIA K23AG031861, NIA P50 AG23501, NIA P01 AG19724]
- Industry-University Cooperative Research Program of California [ITL-BIO04-10148]
- Alzheimer's Association
- John Douglas French Alzheimer's Foundation
- GE Healthcare
- NIH (NCI [SPORE 2P50CA097257, RO1 CA127612-01A1, PO1CA118816-01A2, R01 CA59880]
- Novartis
- State of California Alzheimer's Center
Objectives: In Alzheimer disease (AD), mounting evidence points to a greater role for synaptic loss than neuronal loss. Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial loss of the CA1 pyramidal neurons themselves. In this cross-sectional study, we tested whether tissue loss in the CA1 apical neuropil layer can be observed in vivo in patients with mild AD. Methods: We performed ultra-high-field 7-T MRI on subjects with mild AD (n = 14) and age-matched normal controls (n = 16). With a 2-dimensional T2*-weighted gradient-recalled echo sequence that was easily tolerated by subjects, we obtained cross-sectional slices of the hippocampus at an in-plane resolution of 195 mu m. Results: On images revealing the anatomic landmarks of hippocampal subfields and strata, we observed thinning of the CA1 apical neuropil in subjects with mild AD compared to controls. By contrast, the 2 groups exhibited no difference in the thickness of the CA1 cell body layer or of the entire CA1 subfield. Hippocampal volume, measured on a conventional T1-weighted sequence obtained at 3T, also did not differentiate these patients with mild AD from controls. Conclusions: CA1 apical neuropil atrophy is apparent in patients with mild AD. With its superior spatial resolution, 7-T MRI permits in vivo analysis of a very focal, early site of AD pathology. Neurology (R) 2010;75:1381-1387
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