期刊
NEUROLOGICAL SCIENCES
卷 35, 期 4, 页码 559-563出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-013-1544-0
关键词
Multiple sclerosis; Cognitive impairment; Processing speed; Anxiety
The aim of this study was to investigate the impact of anxiety on the cognitive performance of a clinical sample of relapsing-remitting (RR) MS patients. One hundred ninety patients (140 females) were included in the study and assessed through the beck depression inventory, the state-trait anxiety inventory and the Rao's brief repeatable battery which assesses cognitive domains most frequently impaired in MS. As for neuropsychological performance, a total of 76 (40 %) subjects fulfilled our criterion for cognitive impairment. Tests most frequently failed by cognitive impairment (CI) patients were those assessing complex attention and information processing speed [Simbol Digit Modalities Test (SDMT), Paced Auditory Serial Auditory Test (PASAT) 3 and 2] and verbal memory. In the univariate analysis, state anxiety was related to failure on the SDMT (p = 0.042), and marginally, to failure on the PASAT-3 (p = 0.068), and to the presence of CI (p = 0.082). Moderate/severe depression was detected in 38 (20 %) patients and fatigue in 109 (57 %). Higher depression scores were related to impairment on the ST (OR = 1.05; 95 % CI 1.01-1.10; p = 0.029).
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