期刊
NEUROLOGICAL SCIENCES
卷 32, 期 5, 页码 757-771出版社
SPRINGER
DOI: 10.1007/s10072-011-0599-z
关键词
TNF-alpha; Central sensitization; Neuropathic pain; Preclinical studies; Neuroinflammation
资金
- Netherlands Organization for Scientific Research (NWO) [VENI 916.76.042]
Tumor necrosis factor-alpha (TNF-alpha) is a principal mediator in pro-inflammatory processes that involve necrosis, apoptosis and proliferation. Experimental and clinical evidence demonstrate that peripheral nerve injury results in activation and morphological changes of microglial cells in the spinal cord. These adjustments occur in order to initiate an inflammatory cascade in response to the damage. Between the agents involved in this reaction, TNF-alpha is recognized as a key player in this process as it not only modulates lesion formation, but also because it is suggested to induce nociceptive signals. Nowadays, even though the function of TNF-alpha in inflammation and pain production seems to be generally accepted, diverse sources of literature point to different pathways and outcomes. In this review, we systematically searched and reviewed original articles from the past 10 years on animal models of peripheral nervous injury describing TNF-alpha expression in neural tissue and pain behavior.
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