期刊
NEUROLOGICAL SCIENCES
卷 31, 期 4, 页码 431-435出版社
SPRINGER
DOI: 10.1007/s10072-010-0238-0
关键词
Nitric oxygen synthase; Perivascular nerves; Sphenopalatine ganglion; Middle cerebral artery occlusion; Rats
资金
- Health Bureau of Shanghai [2006Y027]
- Educational Bureau of Shanghai [08YZ36]
- Shanghai Municipal Natural Science Foundation [08ZR1413700]
- Shanghai Science and Technology Development Funds [09QA1403800]
- National Natural Science Foundation of China [30801069]
Blocking or impairment of the sphenopalatine ganglia (SPG) is an effective therapy of cluster headache and other pain syndromes. Contrarily, unilateral SPG-stimulation reduces infarction size in the rat permanent suture model. Well, what are the effects of the SPG damage on the following brain ischemia? This study was aimed to investigate the effects of resection of the nerves bundle from the SPG of rat on the brain lesions following middle cerebral artery occlusion (MCAO), and evaluated the roles of the nitric oxygen synthase (NOS) immunoreactive perivascular nerves of cerebral arteries in MCAO. We found that 7 days after bilateral resections of the nerves bundle from the SPG, the NOS activity perivascular nerves in the middle cerebral arteries disappeared, and the infarction volume and the TUNEL positive cells increased significantly after 24 h MCAO, which implicated that the NOS contained nerves from the SPG maybe have an important role in the MCAO.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据