期刊
NEUROLOGICAL SCIENCES
卷 32, 期 3, 页码 369-374出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-010-0402-6
关键词
Cell proliferation; Electroacupuncture; Hippocampus; Neurogenesis
资金
- Medical Science Academy of Henan
- Department of Education of Henan Province
- National Natural Science Foundation of China
- Ministry of Education of China
To investigate the effect of electroacupuncture on cell proliferation and differentiation in young rat hippocampus, postnatal day-14 rats were assigned randomly to control, ketamine anesthesia, nonacupoint, or acupoint electroacupuncture groups. Electroacupuncture was applied at bilateral acupoints (Quchi, Waiguan, Huantiao, and Zusanli) 30 min daily for 7 successive days. The proliferation and neuronal differentiation of proliferated surviving cells in the dentate gyrus were evaluated at 4 weeks after last stimulation. The stimulatory effect of electroacupuncture on cell proliferation had a long-lasting effect, as indicated by the increased phosphor-histone H3-positive cells. The number of proliferated and survival cells, indicated by BrdU labeling, was highest in the electroacupuncture group. The number of newly differentiated neurons, as indicated by BrdU/NeuN double labeling, was significantly higher in the electroacupuncture group than in any of the other groups. This finding provides a theoretical basis for the clinical application of acupuncture to cerebral injury rehabilitation in children.
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