期刊
NEUROLOGICAL SCIENCES
卷 29, 期 -, 页码 S247-S249出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-008-0952-z
关键词
fatigue; pathophysiology; exercise therapy; cognitive behavioral therapy; drug therapy
Fatigue is a psychophysiological state that acts on the subject's motivation to engage in and/ or to continue strenuous physical or cognitive activities. In various pathological conditions fatigue seems to lose this homeostatic function and presents itself as a symptom. The pathophysiology of fatigue is complex and includes neurological (central and peripheral) dysfunction, and altered neurotransmitter, cytokine, and hormonal settings. Treatment interventions are generally based on a sequential approach including treatment of comorbid factors, nonpharmacological treatments, and drugs.
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