期刊
NEUROLOGIC CLINICS
卷 31, 期 2, 页码 491-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2013.01.005
关键词
Guillain-Barre syndrome; Acute inflammatory demyelinating polyneuropathy; Acute motor axonal neuropathy; Acute motor and sensory axonal neuropathy; Miller Fisher syndrome; Bickerstaff brainstem encephalitis; Diagnosis; Nerve conduction testing
资金
- NCATS NIH HHS [UL1 TR000001] Funding Source: Medline
Guillain-Barre syndrome (GBS) is characterized by rapidly evolving ascending weakness, mild sensory loss, and hyporeflexia or areflexia. Acute inflammatory demyelinating polyneuropathy was the first to be recognized over a century ago and is the most common form of GBS. Axonal motor and sensorimotor variants have been described in the last three decades and are mediated by molecular mimicry targeting peripheral nerve motor axons. Other rare phenotypic variants have been recently described with pure sensory variant, restricted autonomic manifestations, and the pharyngeal-cervical-brachial pattern. It is important to recognize GBS and its variants because of the availability of equally effective therapies in the form of plasmapheresis and intravenous immunoglobulins.
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