期刊
NEUROLOGIC CLINICS
卷 26, 期 3, 页码 675-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2008.03.011
关键词
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资金
- NIA NIH HHS [R01 AG006127-22, R37 AG006127, R01 AG006127] Funding Source: Medline
- NINDS NIH HHS [P01 NS032623-20, T32 NS007321, P01 NS032623, T32 NS007321-20] Funding Source: Medline
Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which virus becomes latent in cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia along the entire neuraxis. Years later, in association with a decline in cell-mediated immunity in elderly and immunocompromised individuals, VZV reactivates and causes a wide range of neurologic disease. This article discusses the clinical manifestations, treatment, and prevention of VZV infection and reactivation; pathogenesis of VZV infection; and current research focusing on VZV latency, reactivation, and animal models.
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