期刊
NEUROLOGIA I NEUROCHIRURGIA POLSKA
卷 46, 期 6, 页码 579-590出版社
ELSEVIER URBAN & PARTNER SP Z O O
DOI: 10.5114/ninp.2012.32354
关键词
neurodegenerative diseases; neurotrophic factors; neurotrophic receptors; stem cell-based therapy
Neurotrophic factors regulate survival, development, and function of nervous tissue. They act via two different classes of receptors and activation of various signaling pathways in the target cells. Illumination of their physiological role in the maintenance of central nervous system homeostasis as well as regeneration of damaged tissue have ignited expectations to heal neurodegenerative diseases, including amyotrophic lateral sclerosis and Parkinson disease. Advances in pharmacotherapy, gene therapy, and stem cell biology have enabled development of novel therapies with application of regenerating cell transplantation. In the foreseeable future, it may lead to the establishment of safe and effective ways of treatment of these severe and currently incurable diseases.
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