1H Magnetic Resonance Spectroscopy in Multiple Sclerosis and Related Disorders

Proton magnetic resonance spectroscopy (H-1-MRS) is an unconventional technique that allows noninvasive characterization of metabolic abnormalities in the central nervous system. H-1-MRS provides important insights into the chemical-pathologic changes that occur in patients with multiple sclerosis (MS). In this review article we present the main brain and spinal cord H-1-MRS features in MS, their diagnostic value in differentiating pseudotumoral demyelinating lesions from primary brain tumors, and their relationship with clinical variables. Last, some data related to the use of H-1-MRS in therapeutic trials is presented.