期刊
NEUROIMAGE
卷 183, 期 -, 页码 972-984出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2018.09.060
关键词
Connectomics; Resting-state; Functional connectivity; Task; Diffusion; Perfusion; Development; Aging; Lifespan
资金
- 14 NIH Institutes and Centers
- McDonnell Center for Systems Neuroscience at Washington University
- Office of the Provost at Washington University
- University of Minnesota Medical School
- [U01MH109589]
- [U01MH109589-S1]
- [U01AG052564]
- [U01AG052564-S1]
- EPSRC [EP/P012361/1, EP/L023067/1] Funding Source: UKRI
- MRC [MR/K006673/1, MR/L009013/1] Funding Source: UKRI
The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据