期刊
NEUROIMAGE
卷 183, 期 -, 页码 745-756出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2018.08.037
关键词
Cognition; White matter hyperintensities; Connectome; Disconnectome; Brain; Aging
资金
- Netherlands Organisation for Health Research and Development [91211021, 90700435]
- VPH-Dare@IT [FP7-ICT-2011-9-601055]
- Netherlands Organisation for Scientific Research [184.033.111]
- Alzheimer Nederland [WE.03-2012-30]
- European Union Seventh Framework Programme (FP7/2007-2013) [FP7-ICT-2011-9-601055]
- Internationale Stichting Alzheimer Onderzoek [12533]
- Erasmus MC and Erasmus University Rotterdam
- Research Institute for Diseases in the Elderly (RIDE)
- Ministry of Education, Culture and Science
- Ministry of Health, Welfare and Sports
- European Commission
- Municipality of Rotterdam
Previous studies have linked global burden of age-related white matter hyperintensities (WMHs) to cognitive impairment. We aimed to determine how WMHs in individual white matter connections relate to measures of cognitive function relative to measures of connectivity which do not take WMHs into account. Brain connectivity and WMH-related disconnectivity were derived from 3714 participants of the population-based Rotterdam Study. Connectivity was represented by the structural connectome, which was defined using diffusion tensor data, whereas the disconnectome represented disconnectivity due to WMH. The relationship between (dis) connectivity and cognitive measures was estimated using linear regression. We found that lower disconnectivity and higher connectivity corresponded to better cognitive function. There were many more significant associations with cognitive function in the disconnectome than in the connectome. Most connectome associations attenuated when disconnection was included in the model. WMH-related disconnectivity was especially related to worse executive functioning. Better cognitive speed corresponded to higher connectivity in specific connections independent of WMH presence. We conclude that WMH-related disconnectivity explains more variation in cognitive function than does connectivity. Efficient wiring in specific connections is important to information processing speed independent of WMH presence.
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