期刊
NEUROIMAGE
卷 93, 期 -, 页码 138-145出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2014.02.016
关键词
Lactate; Oxidative metabolism; Motor stimulation; H-1 MR spectroscopy; Cerebral metabolic rate; Neurotransmitter; Glutamate
资金
- Centre d'Imagerie Bio-Medicale (CIBM) of the University of Lausanne (UNIL)
- Swiss Federal Institute of Technology Lausanne (EPFL)
- University of Geneva (UniGe)
- Centre Hospitalier Universitaire Vaudois (CHUV)
- Hopitaux Universitaires de Geneve (HUG)
- Leenaards Foundation
- Jeantet Foundation
- SNF [131087]
Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate (below 03 mu mol/g) during visual stimulation. These studies have been limited to the visual cortex because of its high energy metabolism and good magnetic resonance spectroscopy (MRS) sensitivity using surface coil. The aim of this study was to extend functional MRS (fMRS) to investigate for the first time the metabolite changes during motor activation at 7 T. Small but sustained increases in lactate (0.17 mu mol/g +/- 0.05 mu mol/g, p < 0.001) and glutamate (0.17 mu mol/g +/- 0.09 mu mol/g, p < 0.005) were detected during motor activation followed by a return to the baseline after the end of activation. The present study demonstrates that increases in lactate and glutamate during motor stimulation are small, but similar to those observed during visual stimulation. From the observed glutamate and lactate increase, we inferred that these metabolite changes may be a general manifestation of the increased neuronal activity. In addition, we propose that the measured metabolite concentration increases imply an increase in Delta CMRO2 that is transiently below that of Delta CMRGlc, during the first 1 to 2 min of the stimulation. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据