期刊
NEUROIMAGE
卷 103, 期 -, 页码 163-170出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2014.09.036
关键词
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资金
- Vienna Spots of Excellence Program of the Centre of Innovation and Technology, City of Vienna (ZIT) [FA102A001]
- University of Vienna
- Medical University of Vienna
- Austrian Science Fund (FWF) [KLI264]
- Austrian Science Fund (FWF) [KLI 264] Funding Source: researchfish
- Austrian Science Fund (FWF) [KLI264] Funding Source: Austrian Science Fund (FWF)
Several investigations have shown limitations of fMRI reliability with the current standard field strengths. Improvement is expected from ultra highfield systems but studies on possible benefits for cognitive networks are lacking. Here we provide an initial investigation on a prominent and clinically highly-relevant cognitive function: language processing in individual brains. 26 patients evaluated for presurgical language localization were investigated with a standardized overt language fMRI paradigm on both 3 T and 7 T MR scanners. During data acquisition and analysis we made particular efforts to minimize effects not related to static magnetic field strength differences. Six measures relevant for functional activation showed a large dissociation between essential language network nodes: although in Wernicke's area 5/6 measures indicated a benefit of ultra highfield, in Broca's area no comparison was significant. The most important reason for this discrepancy was identified as being an increase in susceptibility-related artifacts in inferior frontal brain areas at ultra high field. We conclude that functional UHF benefits are evident, however these depend crucially on the brain region investigated and the ability to control local artifacts. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
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